Colleges & Faculties

Curriculum Vitae

I. Personal information

Zili Lin,Ph.D,Associate Professor.

Professional Experience:
[1] Feb 2021–Present: Associate Professor, College of Animal Science and Technology, Beijing University of Agriculture;
[2] Dec 2019–Feb 2021: Associate Research Fellow, School of Life Sciences, Tsinghua University;
[3] Mar 2016–Dec 2019: Postdoctoral Researcher / Assistant Research Fellow, School of Life Sciences, Tsinghua University.

Education:
[1] Sep 2012–Mar 2016: Ph.D. in Animal Science, Chungbuk National University, Republic of Korea;
[2] Jul 2010–Aug 2012: Assistant Engineer, Institute of Zoology, Chinese Academy of Sciences;
[3] Sep 2007–Jun 2010: M.S. in Animal Science, Beijing University of Agriculture;
[4] Sep 2003–Jun 2007: B.S. in Veterinary Medicine, Shandong Agricultural University.

II. Research interests

Animal Genetics, Breeding, and Reproduction

III. Research Projects

1.(Project No. 2008ZX08008-005-04) National Major Special Project on the Development of New Genetically Modified Organism Varieties: First-level subproject “Breeding of Transgenic Sheep Resistant to Arthritis-Encephalitis”; participant.

2.(Project No. PJ011126) BioGreen21 Project, Republic of Korea: Regulation of Embryonic Developmental Quality; 2012–2014, Rural Development Administration (RDA), Ministry of Agriculture, Republic of Korea; Principal Investigator.

3.(Project No. 5076016182/023) Beijing University of Agriculture Young Faculty Research and Innovation Capacity Enhancement Program: “Establishment and Optimization of a Mouse Embryonic Diapause System” (2022–2023); Principal Investigator.

4.(Project No. 31725018) National Science Fund for Distinguished Young Scholars (Tsinghua University): “Chromatin Reprogramming and Gene Expression Regulation during Mouse Oocyte Development”; participant.

5.(Project No. KM202210020003) General Project of the Beijing Municipal Education Commission:“Mechanisms and Functions of Transcription Factor Distribution during Mouse Embryonic Diapause”(2022–2024); Principal Investigator.

6.(Project No. Z181100001318006) Beijing Municipal Science and Technology Commission—Frontier Innovation Program in Life Sciences: “Genome Activation in Early Embryos and Its Association with Abnormal Development” (2018–2021); participant.

7.(Project No. 2023YJS010) Beijing University of Agriculture Graduate Education Reform and Development Project (2023): “Innovative Teaching Model for the Course‘Advances in Molecular Biology’”; Principal Investigator.

8.(Project No. 横20250203) Provision of In Vitro Cultured Mouse Embryos and Lineage-Segregated Embryos; Tsinghua University – RMB 150,000; Principal Investigator.

9.(Project No.横20250065) Establishment of an Embryonic Diapause Technology System; Yantai Huixun Specialized Cooperative – RMB 150,000; Principal Investigator.

10.(Project No. 32472955) National Natural Science Foundation Project: “Molecular Mechanisms by which Astaxanthin Promotes Testosterone Synthesis in Leydig Cells of Breeder Roosters via the SIRT1/PGC-1α/Mitochondrial Axis”; participant.

11.(Project No. 2025YJS003) Beijing University of Agriculture Graduate Education Reform and Development Project (2025): “Bilingual Course Development for ‘Advances in Molecular Biology’”; Principal Investigator.

IV. Major Achievements

For the first time internationally, revealed the evolutionary conservation and species specificity of epigenetic information reprogramming, such as enhancers in mammalian embryos, and established comprehensive databases for reproduction and breeding (*Sci Adv*, 2021; *NCB*, 2024).

Established a database for epigenomic regulation patterns in early mammalian embryos, and discovered the conservation of offspring chromatin regulation patterns alongside species specificity in pigs, cattle, and humans (*Nature*, 2018; *NCB*, 2022).

Revealed the endometrial developmental mechanisms during early embryo implantation in dairy cows, exploring targeted diagnostic and intervention strategies for pregnancy diseases.

Elucidated the mechanisms of DNA damage and repair during oocyte maturation in cattle and pigs, facilitating solutions to problems such as embryonic arrest in livestock reproduction.

(Ⅰ) Major prize-winning achievements

1. Third Prize, 24th Beijing Youth Academic Speech Contest (2023).

2. Expert Judge, 25th Beijing Youth Academic Speech Contest (2024)

3. Second Prize, 3rd National Young Teachers Competition in Animal Anatomy and Histology & Embryology in Higher Education Institutions (2025).

4. Expert, Pet Branch of the China Association of Agricultural Products Marketing (2024).

5. Industrial Science and Technology Commissioner, Beijing “Thousands of Experts Serving Thousands of Enterprises” Initiative (2023).

6. Reviewer, Agricultural Professional Title Evaluation Committee (2025).

(Ⅱ) Representative papers

1. Wu JY#, Xu JW#, Liu BF#, Yao GD#, Wang PZ#, Lin ZL#, Huang B, Wang XP, Li T, Shi SL, Zhang N, Duan FY, Ming J, Zhang XY, Niu WB, Song WY, Jin HX, Guo YH, Dai SJ, Hu LL, Fang LL, Wang QJ, Li YY, Li W, Na J, Xie W, Sun YP. Chromatin Analysis in Human Early Development Reveals Epigenetic Transition During ZGA. Nature. 2018; 557: 256–260. (#Co-first author).

2. Xiong ZQ#, Xu K#, Lin ZL#, Kong F#, Wang QJ#, Quan YJ#, Sha QQ, Li FJ, Li L, Xie W. Ultrasensitive Ribo-seq reveals translational landscapes during oocyte-to-embryo transition and early development, NAT CELL BIOL. 2022; 24, 968–980. (#Co-first author).

3. Bofeng Liu#, Yuanlin He#， Xiaotong Wu#, Zili Lin#, Jing Ma#,Yuexin Qiu, Yunlong Xiang, Feng Kong, Fangnong Lai Mrinmoy Pal, Peizhe Wang, Jia Ming7, Bingjie Zhang, Qiujun Wang, Jingyi Wu, Weikun Xia, Weimin Shen, Jie Na, Maria-Elena Torres-Padilla, Jing Li  & Wei Xie Mapping putative enhancers in mouse oocytes and early embryos reveals TCF3/12 as key folliculogenesis regulators. NAT CELL BIOL. 2024; 26, 962–974. (#Co-first author).

4. Lin ZL, Xu YN, Namgoong S, Kim NH. JMY Functions as Actin Nucleation-Promoting Factor and Mediator for p53-Mediated DNA Damage in Porcine Oocytes. PLOS ONE. 2014; 9(10): e109385.

5. Lin ZL, Ni HM, Liu YH, Sheng XH, Cui XS, Kim NH, Guo Y. Effect of anti-PMSG on Distribution of Estrogen Receptor Alpha and Progesterone Receptor in Mouse Ovary, Oviduct and Uterus. Zygote. 2015; 23(5):695-703.

6. Lin ZL, Li YH, Xu YN, Wang QL, Namgoong S, Cui XS, Kim NH. Effects of Growth Differentiation Factor 9 and Bone Morphogenetic Protein 15 on the in Vitro Maturation of Porcine oocytes. Reprod Domest Anim. 2014; 49(2):219-27.

7. Lin ZL, Kim NH. Role of Ataxia-Telangiectasia Mutated (ATM) in Porcine Oocyte in vitro Maturation. Cell Biol Int. 2015; 17; 39(6):710-20.

8. Lin ZL, Cui XS, Namgoong S, Kim NH. Junction-mediating and regulatory protein (JMY) is Essential for Early Porcine Embryonic Development. J Reprod Dev. 2015; 61(5):361-7.

9. Lin ZL, Li YH, Jin YX, Kim NH. A Maternal Transcription Factor, Junction Mediating and Regulatory Protein is Required for Preimplantation Development in the Mouse. Dev Reprod. 2019 23(3), 285-295.

10. Ji SY, Chen FL, Stein P, Wang JC, Zhou ZM, Wang LJ, Zhao Q, Lin ZL, Liu BF, Schultz RM, Xie W. OBOX regulates murine zygotic genome activation and early development. Nature. 20230717.

11. Li LJ, Lai FN, Hu XY, Liu BF, Lu XK, Lin ZL, Liu L, Xiang YL, Frum T, Halbisen MA, Chen FL, Fan Q, Ralston A, Xie W Multifaceted SOX2-chromatin interaction underpins pluripotency progression in early embryos, Science, 20231215.

12. Liu BF #, Xu QH #, Wang QJ #, Feng S, Lai FN, Wang PZ, Zheng FY, Xiang YL, Wu JY, Nie JW, Qiu C, Xia WK, Li LJ, Yu G, Lin ZL, Xu K, Xiong ZQ, Kong F, Liu L, Huang CY, Yu Y, Na J, Xie W. The landscape of RNA Pol II binding reveals a stepwise transition during ZGA. Nature. 2020; 587, 139-144.

13. 林自力,高雅,邓桂馨,梁鸿斌,张鸿波,刘云海,倪和民,郭勇,王志刚. PMSG 和 FSH 同期发情处理对小鼠子宫，卵巢和输卵管中雌激素 α 受体分布的影响. 中国实验动物学报［J］. 2010，18(3) :204-207.

14. 林自力, 倪和民, 郭勇, 梁鸿斌, 尹艳云, 邓桂馨, 刘云海. PMSG 和 FSH 同期发情处理对小鼠卵巢，输卵管和子宫中受体分布的影响. 中国比较医学杂志［J］. 2011,21(5): 11-14.

15. 林自力, 何艳芳, 卢婷婷, 康 蕊, 秦秀蕊, 张 鑫, 倪和民. 稀释液中分别添加不同浓度咖啡因或谷胱甘肽对犬精液冷冻效果的影响. 中国农学通报［J］. 2010,26(8):21-24.

V. Contact information

Postal address: College of Animal Science and Technology, Beijing University of Agriculture, No. 7, Beinong Road, Huilongguan, Changping, Beijing, 102206

Contact number: 18800171219

Email: talzl@163.com