Colleges & Faculties

Curriculum Vitae

I.  Personal information

Suying Cao, Ph.D., Professor.

Professional Experience:
[1] Jan 2026–Present: Professor, College of Animal Science and Technology, Beijing University of Agriculture;

[2] Sep 2018–Jan 2026: Associate Professor, College of Animal Science and Technology, Beijing University of Agriculture;

[3] Jul 2013–Sep 2018: Lecturer, College of Animal Science and Technology, Beijing University of Agriculture;

[4] Aug 2009–Jul 2010: Research Assistant, Stem Cell and Developmental Biology Group, Genome Institute of Singapore;

[5] Aug 2007–Aug 2009: Research Assistant, Molecular Breeding Laboratory, Temasek Life Sciences Laboratory, Singapore;

[6] Jul 2004–Aug 2007: Lecturer, College of Animal Science and Technology, Hebei Agricultural University.

Education:
[1] Aug 2010–Jul 2013: Ph.D. in Biochemistry and Molecular Biology, China Agricultural University;

[2] Sep 2001–Jul 2004: M.S. in Ruminant Nutrition, Hebei Agricultural University;

[3] Sep 1994–Jul 1998: B.S. in Animal Nutrition, Hebei Agricultural University.

II. Research interests

Stem cells and early embryonic development.

III. Research Projects

1.(Project No. 2023ZD0407504) The Major Agricultural Biotechnology Breeding Project of the Ministry of Agriculture and Rural Affairs: "Technological Innovation of Multi-Potent Stem Cell Lines for Cattle and Sheep and Their Directed Differentiation into Gametes"; participant.

2.(Project No. 6192005) Beijing Natural Science Foundation General Project "Research on the Regulatory Mechanism of LncRNA XLOC_040580 in Zygote Activation of Early Pig Embryos"; Principal Investigator

IV. Major Achievements

Overcame single-cell isolation of E0–14 livestock pre-implantation embryos and produced the first high-quality single-cell maps for pig and sheep, defining naïve, intermediate, and primed pluripotency regulation of the epiblast; established stable pig, sheep, and cattle ESC lines (>300 passages) that tolerate multiple gene-editing rounds and directionally differentiate into muscle, adipose, and germ cells, enabling cell-cultured meat and gene-edited cloned pig research (Cell Res 2022; Adv Sci 2025, corresponding author).

Built a single-cell lncRNA expression atlas of porcine pre-implantation embryos and a GFP-tracked zygotic microinjection system; demonstrated that XLOC-040580 targets TPRA1 to raise blastocyst rate and embryo cell number and to engage the pluripotency network, providing new targets for porcine in vitro embryo production and livestock ESC line establishment (Protein Cell 2018; Cell Transpl 2025, corresponding author).

(Ⅰ) Representative papers

1.Tracing and Capturing the Epiblast Pluripotency of Sheep Preimplantation Embryos. Zhang J, Li R, Luo R, Zhang Q, Zhao Z, Xu H, Zhi M, Jiang W, Wang M, Chen X, Feng Z, Wang Y, Yang Y, He P, Su H, Chen T, Wang S, Yao Y, Yang J, Zhao F, Li T, Wang H, Zhang X, Zhang J, Liu Q, Gao S, Yao Y, Han J, Cao S. Adv Sci (Weinh). 2025 Sep;12(36):e17764.

2.FRRS1L variants and ferriheme overload drive hyperpigmentation and systemic Iron overload in lanping black bone sheep. Han D, Zhang Y, Deng W, Yang X, Chen J, Hua G, Darwish HYA, Mao H, Gou X, Wang J, Cui K, Ma Y, Tai Y, Dong X, Yao Y, Yang Z, Cao S, Yu Z, Liu W, Deng X. Cell Biosci. 2025 Jun 24;15(1):87.

3.LncRNA XLOC-040580 targeted by TPRA1 coordinate zygotic genome activation during porcine embryonic development. Liu M, Li E, Mu H, Zhao Z, Chen X, Gao J, Gao D, Liu Z, Han J, Zhong L, Cao S. Cell Transplant. 2025 Jan-Dec;34:9636897251332527.

4.Elucidation of the pluripotent potential of bovine embryonic lineages facilitates the establishment of formative stem cell lines. Zhi M, Gao D, Yao Y, Zhao Z, Wang Y, He P, Feng Z, Zhang J, Huang Z, Gu W, Zhao J, Zhang H, Wang S, Li X, Zhang Q, Zhao Z, Chen X, Zhang X, Qin L, Liu J, Liu C, Cao S, Gao S, Yu W, Ma Z, Han J. Cell Mol Life Sci. 2024 Oct 8;81(1):427.

5.Generation of three-dimensional meat-like tissue from stable pig epiblast stem cells. Zhu G, Gao D, Li L, Yao Y, Wang Y, Zhi M, Zhang J, Chen X, Zhu Q, Gao J, Chen T, Zhang X, Wang T, Cao S, Ma A, Feng X, Han J. Nat Commun. 2023 Dec 9;14(1):8163.

6.Generation of stable integration-free pig induced pluripotent stem cells under chemically defined culture condition. Zhu Q, Wang F, Gao D, Gao J, Li G, Jiao D, Zhu G, Xu K, Guo J, Chen T, Cao S, Zhi M, Zhang J, Wang Y, Zhang X, Zhang D, Yao Y, Song J, Wei HJ, Han J. Cell Prolif. 2023 Nov;56(11):e13487.

7.Research progress and application prospects of stable porcine pluripotent stem cells. Zhang J, Zhi M, Gao D, Zhu Q, Gao J, Zhu G, Cao S, Han J. Biol Reprod. 2022 Jul 25;107(1):226-236.

8.Generation and characterization of stable pig pregastrulation epiblast stem cell lines. Zhi M, Zhang J, Tang Q, Yu D, Gao S, Gao D, Liu P, Guo J, Hai T, Gao J, Cao S, Zhao Z, Li C, Weng X, He M, Chen T, Wang Y, Long K, Jiao D, Li G, Zhang J, Liu Y, Lin Y, Pang D, Zhu Q, Chen N, Huang J, Chen X, Yao Y, Yang J, Xie Z, Huang X, Liu M, Zhang R, Li Q, Miao Y, Tian J, Huang X, Ouyang H, Liu B, Xie W, Zhou Q, Wei H, Liu Z, Zheng C, Li M, Han J. Cell Res. 2022 Apr;32(4):383-400.

9.Berberine regulates lipid metabolism via miR-192 in porcine oocytes matured in vitro. Dai J, Huang X, Zhang C, Luo X, Cao S, Wang J, Liu B, Gao J. Vet Med Sci. 2021 May;7(3):950-959.

10.IRF-1 expressed in the inner cell mass of the porcine early blastocyst enhances the pluripotency of induced pluripotent stem cells. Shi B, Gao D, Zhong L, Zhi M, Weng X, Xu J, Li J, Du X, Xin Y, Gao J, Zhu Q, Cao S, Liu Z, Han J. Stem Cell Res Ther. 2020 Nov 27;11(1):505.

11.Mthfd2 Modulates Mitochondrial Function and DNA Repair to Maintain the Pluripotency of Mouse Stem Cells. Yue L, Pei Y, Zhong L, Yang H, Wang Y, Zhang W, Chen N, Zhu Q, Gao J, Zhi M, Wen B, Zhang S, Xiang J, Wei Q, Liang H, Cao S, Lou H, Chen Z, Han J. Stem Cell Reports. 2020 Aug 11;15(2):529-545.

12.Implantation initiation of self-assembled embryo-like structures generated using three types of mouse blastocyst-derived stem cells. Zhang S, Chen T, Chen N, Gao D, Shi B, Kong S, West RC, Yuan Y, Zhi M, Wei Q, Xiang J, Mu H, Yue L, Lei X, Wang X, Zhong L, Liang H, Cao S, Belmonte JCI, Wang H, Han J. Nat Commun. 2019 Jan 30;10(1):496.

13.Long non-coding RNAs involved in the regulatory network during porcine pre-implantation embryonic development and iPSC induction. Zhong L, Mu H, Wen B, Zhang W, Wei Q, Gao G, Han J, Cao S. Sci Rep. 2018 Apr 27;8(1):6649.

14.Lineage specification revealed by single-cell gene expression analysis in porcine preimplantation embryos. Wei Q, Li R, Zhong L, Mu H, Zhang S, Yue L, Xiang J, Li E, Zhi M, Cao S, Han J. Biol Reprod. 2018 Aug 1;99(2):283-292.

15.Lipid Supplement in the Cultural Condition Facilitates the Porcine iPSC Derivation through cAMP/PKA/CREB Signal Pathway. Zhang W, Wang H, Zhang S, Zhong L, Wang Y, Pei Y, Han J, Cao S. Int J Mol Sci. 2018 Feb 8;19(2):509.

16.Pluripotent stem cells secrete Activin A to improve their epiblast competency after injection into recipient embryos. Xiang J, Cao S, Zhong L, Wang H, Pei Y, Wei Q, Wen B, Mu H, Zhang S, Yue L, Yue G, Lim B, Han J. Protein Cell. 2018 Aug;9(8):717-728.

17.曹素英,李瑞岐,张少鹏,等. 应用猪冷冻精液进行卵子胞质单精子注射生产胚胎 [J]. 农业生物技术学报, 2017, 25 (05): 813-819.

18.曹素英,韩建永,李建国. 哺乳动物体细胞克隆后生重新编程有关机理研究进展 [J]. 中国畜牧兽医, 2005, (02): 33-36.

19.曹素英,李建国,韩建永,等. 波尔山羊育肥期能量和蛋白质营养需要的研究 [J]. 畜牧与兽医, 2005, (01): 7-9.

V. Contact information

Postal address: College of Animal Science and Technology, Beijing University of Agriculture, No. 7, Beinong Road, Huilongguan, Changping, Beijing, 102206

Contact number: 15201429635

Email: 20137602@bua.edu.cn