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Guo Wei
Author: Time:2013-09-30 14:04:30

Department of Plant Protection

Plant Science and Technology College
Beijing University of Agriculture,No.7, Beinong Road, Huilongguan,

Changping, Beijing, 102206





2001-2005 Ph.D. Sun Yat-sen University,China & Cornell University, U.S.A.

1998-2000 M.S. Northeast Agricultural University & Institute of Plant Protection, Chinese Academy of Agricultural Science

1990-1994 B.A. Northeast Agricultural University

Areas of Expertise

Insect physiology and biochemistry; biochemistry and molecular biology of the insect midgut; interaction of insects with microbial pathogens and host plants; toxicology of insecticides.



Our research is focused on the understanding of the biochemical and molecular basis of insect midgut physiology and interactions of the midgut with host plants and microbial pathogens. The insect midgut is the primary site interfacing with chemical, physical and biological factors from the environment. Interactions of the insect midgut with various chemical compounds from host plants may determine the toxicity or deterrency of plant compounds to insects.

In insects, the gut epithelium is lined by a unique protein-chitin structure, the peritrophic membrane (PM). Our previous research on the PM has led to the identification of some PM proteins from several insects. We are using multiple approaches, including physiological, biochemical, proteomic and molecular approaches, to further our understanding of the roles of PM proteins and function. Our projects include National Natural Science of Foundation of China and the National Basic Research Program of China(973 program)(Sub-topic),et. al.


Extension and Outreach

Our extension focus is on developing and applying molecular techniques in insect pest management (IPM) programs. Our projects include China Agriculture Research System.


Selected Publications (*Author for correspondence)

·         Wei Guo, Guoxun Li, Yi Pang and Ping Wang. A novel chitin binding protein identified from the peritrophic membrane of the cabbage looper, Trichoplusia ni.  Insect Biochem. and Mol. Biol. 2005,35(11):1224-1234.( SCIF4.018)

·         Shangling Fang, Li Wang, Wei Guo*, Xia Zhang, Donghai Peng, Chunping Luo, Ziniu Yu and Ming Sun. Bacillus thuringiensis Bel protein synergizes the toxicity of Cry1Ac protein to Helicoverpa armigera larvae by degrading insect intestinal mucin. Appl Environ Microbiol. 2009,75(16):5237-5243.(SCIIF4.004)

·         Xia Zhang, Wei Guo*. Isolation and identification of an insect intestinal mucin HaIIM86--the new target for Helicoverpa armigera biocontrol. International Journal of Biological Sciences. 2011,7(3):286-296.(SCIIF3.215)

·         Jiao Yin, Zhao-Jun Wei, Ke-Bin Li, Ya-Zhong Cao, Wei Guo*. Identification and Molecular Characterization of a New Member of the Peritrophic Membrane Proteins from the Meadow Moth, Loxostege Sticticalis. International Journal of Biological Sciences. 2010,6:504-511(SCIIF3.215)

·         Weiming Sun, Lina Feng, Wei Guo*, Daqun Liu, Zhihui Yang, Lifeng Liu, Dan Zhao, Longxian Ran and Qingfang Meng. First Report of Neocosmospora striata Causing Peanut Pod Rot in China. Plant Disease.2012,96(1):146. ( SCIIF2.447)

·         Weiming Sun, Lina Feng, Wei Guo*, Daqun Liu, Yaning Li and Longxian Ran. First Report of Peanut Pod Rot Caused by Neocosmospora vasinfecta in Northern China. Plant Disease.2012,96(3):455.( SCIIF2.447)

·         Xiaomin Liu, Jie Li, Wei Guo*,Daqing Xu. Identification of a new chitinase protein from larval Holotrichia oblita (Coleoptera: Melolonthidae). The 2011 5th International Conference on Bioinformatics and Biomedical Engineering. 2011,1:452-456.(EI)

·         Li Xinna, Li Ruijun, Xu Daqing, Guo Wei *, Sun Weiming, Zhao Dan, Liu Daqun. Eukaryotic expression and biochemical characteristic analysis of intestinal mucin SeIIM8 from Spodoptera exigua (Hübner) (Lepidoptera : Noctuidae) African Entomology.2012, 20(2):252-258.SCIIF0.47

·         Chen Jianwu, Sun Fan, Shi Yongxia, Xu Wei, Guo Wei, Pang Yi. Efficient expression of vip184ΔP gene under the control of promoters plus Shine-Dalgarno (SD) sequences of cry genes from Bacillus thuringiensis.Journal of Applied Microbiology.2005,99(2): 426-434. SCIIF2.365

·         Jiao Yin, Tao Zhong, Zhao-Jun Wei, Ke-Bin Li, Ya-Zhong Cao and Wei Guo. Molecular characters and recombinant expression of the carboxylesterase gene of the meadow moth Loxostege sticticalis L.(Lepidoptera: Pyralidae).African Journal of Biotechnology. 2011, 10 (10):1794-1801. (SCIIF0.573)

·         Dan Zhao, Wei Guo *Weiming Sun, Daqing Xu, Daqun Liu. Identification of a novel enhancin-like gene from Bacillus thuringiensis. Front. Agric. China, 2011,5(4):423-429.

·         Weiming Sun, Wei Guo *, Daqun Liu, Tinghui Liu, Lina Feng, Lianna Liu, Yaning Li and Yakun Zhang. Construction of a fosmid genomic library of Streptomyces roseoflavus men-myco-93-63. Front. Agric. China2011,5(4):576-580.

·         Liguang Wang, Wei Guo *, Jianxin Tan, Weiming Sun, Tinghui Liu,Yongxiang Sun. Construction of an engineering strain expressing cry7Ab7 gene cloned from Bacillus thuringiensis. Front. Agric. China, 2010,4(3) :328-333.

·         Tinghui Liu, Wei Guo *, Weiming Sun and Yongxiang Sun. Biological characteristics of Bacillus thuringiensis strain Bt11 and identication of its cry-type genes. Front. Agric. China. 2009,3(2):159-163.

·         Xia Zhang, Guoxun Li, Wei Guo *. Molecular cloning and sequencing of SeIIM-8, an insect intestinal mucin cDNA from Spodoptera exigua. International symposium on insect midgut biology program and abstracts. South China Normal University, Guangzhou, China. 2008.

·         Wei Guo, Guoxun Li and Ping Wang. A chitin deacetylase-like protein identified from cabbage looper, Trichoplusia ni. The 9th International Colloquium of Invertebrate Pathology and Microbial Control (ICIPMC). 2006. Wuhan. China

·         Wei Guo, Guoxun Li and Ping Wang. Inheritance of resistance and effect of PM on toxicity of Bacillus thuringiensis toxin Cry1Ac in cabbage looper, Trichoplusia ni. The 9th International Colloquium of Invertebrate Pathology and Microbial Control (ICIPMC). 2006. Wuhan. China.

·         Guo Wei, Li Guoxun and Wang Ping. Unique chitin binding proteins are primary building blocks in type I peritrophic membrane formation. The 52nd Annual Meeting of the Entomological Society of America Entomology and ESA. 2004. Salt Lake City. USA.

·         Liu Xiao-min, Li Jie, Guo Wei*,Xu Da-qing and Zhang Xia. Cloning,expression and histolocalization of an intestinal mucin gene HM72 from Helicoverpa armigera(Hubner)(Lepidoptera:Noctuidae), Acta Entomologica Sinica,2011,542: 127-135.

·         Liu Xiao-min, Li Jie, Guo Wei*, Zhang Xia and Li Xin-na. Cloning,expression and activity of Carboxylesterase gene from Helicoverpa armigera(Hubner). Scientia Agricultura Sinica, 2011, 444:730-737.

·         Yongxiang Sun, Tinghui Liu, Wei Guo*. Liguang Wang and Weiming Sun.Cloning and characterization of a novel gene cry9Ea7 encoding crystal protein with high toxicity against Trichoplusia ni. Acta Microbiologica Sinica, 2010505):601-605.

·         Li Wen, Guo Wei*, Zhang Xia, Li Jie and Sun Wei-ming. Cloning, sequencing and detection of tissue-specific expression of the intestinal protein gene SeM-8 from Spodoptera exigua peritrophic membrane. Acta Entomologica Sinica, 2010, 537:727-733.

·         Jianru Shen, Mingyu Hou and .Wei Guo*. Identification and Cloning of vip3A genes from isolates of Bacillus thuringiensis and their bioactivity analysis. Acta Microbiologica Sinica, 2009491):110-116.

·         Zhang Xia, Guo Wei*,Li Guo-xun and Song Shui-shan. Cloning, expression and sequence analysis of carboxylesterase gene from Spodoptera exigua. Acta Entomologica Sinica,2008, 517):681-688.

·         Zhang Xia, Li Guo-xun and Guo Wei*. Molecular cloning and sequencing of an insect intestinal mucin cDNA from Spodoptera exigua. Scientia Agricultura Sinica, 20084111):3898-3904.

·         Weiming Sun, Guo Wei* and Daqun Liu. Efficent detection and analysis of linear plasmid in Stremptomyces Men-myco-93-63. Acta Microbiologica Sinica, 2008,48(12):1-4.